Greenselect® Indena Phytosome™
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Greenselect® Indena Phytosome™
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Pharmacokinetics innovation1
The distinctiveness of Indena’s proprietary delivery system emerges clearly when observing the difference between the plasma concentration profiles of two different catechin extracts, with or without Indena Phytosome™ formulation: Greenselect® Indena Phytosome™ and Greenselect®.
Plasma EGCG profiles in healthy subjects were monitored after ingestion of a single dose of one of the two preparations, containing 240 mg of tea catechins each. After 2 hours, the difference in peak concentration was significantly different: EGCG concentration with Greenselect® Indena Phytosome™ was more than doubled and remained higher over time (Fig. 1).
Furthermore, the optimized catechins profile reflects also to an improved antioxidant activity, compared to traditional green tea extract.
Figure 1: Plasma EGCG profile after ingestion of a single dose of Greenselect® Indena Phytosome™ or Greenselect®.2
Weight balance2,3
Multiple clinical studies have demonstrated that green tea catechins, play a coadjuvant role in weight management when combined with a low-calorie diet thanks to their capacity to enhance caloric expenditure through increased thermogenesis.
Greenselect® Indena Phytosome™ further exploits catechins benefits, delivering clinical efficacy as proven in different populations.
In one 90-day study, overweight participants following a balanced hypocaloric diet showed remarkable improvements when supplemented with Greenselect® Indena Phytosome™: while the control group (diet only) experienced an average BMI reduction of 5%, those also taking the supplement achieved a significantly higher reduction of 12% (p<0.001 vs. baseline). A notable decrease in waist circumference was also observed, particularly among male subjects (Fig. 2 and 3).
Further evidence from another randomized study in menopausal women, evaluated key indicators of adipose tissue function - respiratory quotient (RQ), resting energy expenditure (REE), carbohydrate oxidation (%CHO), and lipid oxidation (%LIP) - at baseline and after 30 and 60 days of supplementation with 150 mg of Greenselect® Phytosome® or placebo. Statistically significant differences were recorded over time in all measured parameters: RQ (p = 0.009), REE (p = 0.009), %CHO (p = 0.0006), and %LIP (p = 0.0006), confirming the ingredient's impact on metabolic dynamics (Fig. 4).
Collectively, these findings establish Greenselect® Indena Phytosome™ as an optimal companion ingredient for individuals requiring support at various stages of life and under different physiological conditions, including borderline body weight and metabolic profiles, menopause, and chronic treatments with GLP-1 products.
Figure 2: Weight management expressed in terms of BMI modulation in the two groups following a low-calorie diet only (A), or following the same diet and taking a daily dose of tablets containing Greenselect® Indena Phytosome™ (B).3
Figure 3: Weight management expressed in terms of waistline measurement difference, in the two groups following a low-calorie diet only (A), or following the same diet and taking a daily dose of tablets containing Greenselect® Indena Phytosome™(B).
Figure 4: Pre-and post-supplementation differences between groups for primary endpoint. The table reports the estimates of time* group (β), 95% confidence interval (CI), and adjusted p-value of the null hypothesis of no effect.
Metabolic health4
Greenselect® Indena Phytosome™ is also proven top offer cardiovascular protection thanks to the demonstrated statistically significant (p<0,05) amelioration of key metabolic parameters including fasting glucose (-7%), triglycerides (-8%), HDL (about +20%) versus baseline, after 6 months supplementation.
Greenselect® Indena Phytosome™ demonstrated a significant impact on metabolic health, with 68% of subjects showing an improvement in their metabolic profile following supplementation.
In contrast, 80% of participants in the control group maintained their initial borderline signature, indicating a lack of spontaneous improvement without intervention.
These results underscore the potential of Greenselect® Indena Phytosome™ as an effective strategy for supporting metabolic balance in at-risk individuals.
Women's health3
Hormonal changes during menopause can lead to modified body composition, increased lipid tissue and weight gain, which represent major risk factors for cardiovascular diseases.
A randomized clinical trial carried out on overweight post-menopausal sedentary women evaluated the effect of Greenselect® Indena Phytosome™ supplementation on the regulation of lipid tissue function, confirming the positive action of the green tea extract in its formulation.
BIBLIOGRAPHY
1. Pietta P. et al., Biochem.Mol. Biol. Intl. 46: 895-903 (1998).
2. Rondanelli M. et al. Nutrients.14(24):5209 (2022).
3. Di Pierro F. et al., Alternative Medicine Review.Volume 14, Number 2 (2009).
4. Belcaro G. et al., Evid Based Complement Alternat Med. Volume 2013:869061 (2013).
