Vazguard® – Bergamot Indena PhytosomeTM
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Vazguard® – Bergamot Indena PhytosomeTM
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Pharmacokinetics innovation1
Vazguard® shows an optimal absorption: in a human study on 60 participants, 20 receiving Vazguard®, demonstrates a 2.5-fold increase in its bioabsorption compared to the unformulated extract.
Metabolic health2
In a double-blind placebo-controlled study, Vazguard® could significantly optimize by -12% the visceral adipose tissue (VAT p<0,0001) in over 60 volunteers:
- significant results could be observed within 1 month;
- the optimization of VAT translated into a global improvement of the glycolipidemic profile;
- the improvement of the lipid profile could also be observed in a wide population in terms of age and gender compared to baseline: total cholesterol, LDL, LDL/HDL ratio, Apo-B/Apo-A ratio;
- a moderate optimization of glycemia was observed, along with a more significant beneficial effect on insulin resistence parameters (HOMA);
- positive modulation of body composition related to parameters such as fat mass and body weight;
- the supplementation supported also the normalization of liver function as reflected by transaminases.
Figure 1: Vazguard effect on total cholesterol (totChol), LDL cholesterol (cLDL), HDL cholesterol (cHDL), tryglicerides (TG) and blood glucose (BGluc), before and after the intervention.
Other scientific evidences
Vazguard® demonstrated to have an activity on gut microflora involved in genesis of abdominal fat, obesity and diabetes.
BIBLIOGRAPHY
1Mollace V. et al.,Endocrine Metabolic& Immune Disorders – Drug Targets 19, 136-143 (2019).
Formisano C. et al,J. Agric. Food Chem. 2019, 67, 3159−3167;
2- Di Donna L et al J Nat Prod 72:1352–1354 5 (2009)
3-
4- Rondanelli M. et al., Phytotherapy Res. 2020, in press;
5- Ramaschi G.,et al, J. Agric. Food Chem. 2019, 67, 3159−3167
6- Riva A. et al., J Appl.Microb Res. 2020, 3 (2), 45-51.
