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NUTRACEUTICALS
Centextra®
Centella Asiatica L. dry extract
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Overview
We’ve set the absolute advantage
Healthy, elastic skin can reflect the body’s internal balance. Scientific evidence shows that processes such as oxidative stress, chronic inflammation, and the gradual decline of structural proteins like collagen can accelerate visible signs of skin aging and weaken skin integrity.1
Centextra® is designed to address these mechanisms from within by combining the well-known benefits of Centella asiatica with advanced Indena Phytosome® technology.1
At the core of Centextra® lies the power of Centella asiatica, a botanical long recognized for its role in skin physiology. Its key constituents are known to stimulate collagen synthesis, support dermal regeneration, and help reinforce the skin’s structural matrix contributing to improved elasticity and overall skin vitality.1
Centextra® into action
Centextra® is a carefully standardized dry extract of Centella asiatica (L.) Urban, developed to preserve the full spectrum of triterpenoid compounds naturally present in the plant, as confirmed by in-depth phytochemical analyses. Among these, asiaticoside, madecassoside, asiatic acid, and madecassic acid represent the key biologically active constituents associated with skin health and integrity.2,3 The power of these compounds is fully leveraged thanks to the Indena Phytosome® delivery system, specifically designed for optimized biological and technological performances.
Indena took its research further with several preclinical studies conducted to investigate the biological activity of Centextra®, evaluating its antioxidant properties, its role in supporting a healthy inflammatory response, and its effects on collagen structure and skin regeneration.4
The results demonstrated that Centextra® significantly reduces intracellular reactive oxygen species (ROS) levels, restoring them toward physiological values in a dose-dependent manner, while also significantly decreasing IL-6 activity, suggesting a promising role in supporting balanced inflammatory response.4
Moreover, scratch assay models showed that Centextra® promotes cell migration and monolayer repair, leading to a closure rate of approximately 40% after 24 hours. The extract also helped restore collagen levels toward physiological conditions and countered collagen degradation mediated by collagenase activity, supporting the maintenance of dermal structural matrix and skin integrity.4
All of this constitutes evidence of the pleiotropic effect of Centextra®.
To further investigate the extract’s efficacy, a clinical study is currently ongoing to evaluate the effects of Centextra® on skin elasticity and firmness, as well as on skin profilometry parameters.5
Find out how Centextra® is one step beyond
As a nutraceutical, Centextra® stands out for the excellence of its core primary ingredient and exact physiochemical identification, with >13% concentration of total triterpenes.4
Indena also takes pride in its exclusively Sardinian supply chain; by working in harmony with local communities, the company ensures an environmentally friendly production process.
The sustainable journey of Centextra®
Starting from raw material sourced from an innovative agricultural hub in Sardinia, Centextra® is made in a facility certified according to ISO 14001 and ISO 45001 standards, where responsible manufacturing practices guide every stage of production. From the reduction of CO₂ emissions to the ongoing transition toward cleaner energy sources, Indena’s process is designed to minimize environmental impact while ensuring the highest standards of occupational health and safety.
This approach reflects a vision that values not only quality and innovation but also respect for the environment and the communities involved in production.
See through science
Peer-reviewed science on Centextra®
Here you can find more scientific evidence for your review.
ACCESS NOWBibliography
1Maramaldi G, Clin Cosmet Investig Dermatol. 2013 Dec 12;7:1-9.
2Masi F, Fitoterapia. 2022 Apr;158:105163.
3Giacomelli L, EsperienzeDermatol. 2018;20:35-7.
4Indena Internal Data.
5Study protocol – Indena Internal Data.
CENTEXTRA® AT A GLANCE
Why choose Centextra®?
01.
Centextra® is a premium food-grade ingredient.
02.
Centextra® is a standardized extract containing a high concentration (≥13%) of triterpenoids.
03.
In vitro studies have shown that Centextra® counteracts oxidative stress and promotes healthy inflammatory response in skin cells.
04.
Preclinical tests have proven that Centextra® promotes regeneration of damaged skin layer and restores physiological collagen levels.
05.
Centextra® can play a significant role in collagen boosting and repair.
06.
Centextra® has outperformed unformulated Centella extract in all the preclinical tests conducted.
07.
Centextra® is made by leveraging environmentally friendly, local production in Sardinia.
Technical data
Common Name
Centella standardized extract
Type
dry extract
Plant source
aerial parts
Health benefit
Antioxidant capacity, Skin health, Healthy aging
Patent
Centextra® is a trademark of Indena S.p.A. The use of Indena’s trademarks is subject to Indena’s authorization.
Specifications
Centextra® is standardized to contain ≥13% total triperpenes by HPLC
Recommended dose and use
150 mg/die
Assay
≥13% total triperpenes by HPLC
Broad category
Healthy aging
These statements may not comply with your country’s laws and regulations or with Reg. EC n. 1924/2006 and have not been evaluated by the Food and Drug Administration. The products are not intended to diagnose, treat, cure or prevent any disease. Marketers of finished products containing this ingredient are responsible for ensuring compliance with the applicable legal framework.
