KEEP YOUR METABOLISM BALANCED, NATURALLY
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NUTRACEUTICALS
Berbevis®
Berberine Phytosome™
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Overview
We’ve set the absolute advantage
Plants from the Berberis genus have been widely used in traditional Asian medicine for their health benefits for centuries; among them, a particular species - Berberis aristata - is also mentioned in the Ayurvedic Pharmacopoeia of India.1
From a scientific point of view, berberine is recognized as a natural derived bioactive alkaloid obtained from the berberis genus plants, proven to favorably modulate blood profiles such as plasma lipids and glucose levels, therefore contributing to metabolic wellbeing.2
Find a way to keep our metabolism balanced is one of our time’s main global health targets, in order to fight multifactorial noncommunicable disorders such as metabolic syndrome, PCOS or type-II diabetes.2
That’s where the journey started. This urgent need gave birth to Berbevis®, your natural ally for a healthy metabolism: an innovative berberine extract obtained from Berberis aristata with an optimized bioabsorption profile, thanks to its Phytosome delivery system.3
Berbevis into action
In recent years, berberine has received widespread attention due to its good potential for optimal metabolic wellbeing during our lifespan.
Its efficacy is linked to the berberine’s so-called “Cloud Effect”: its pleiotropic action that simultaneously affects either root causes (e.g. low-grade chronic inflammation, oxidative stress, gut microbiota modulation) or visible effects (e.g. insulin response) through the modulation of several cellular targets (e.g. AMPK, mitochondria, insulin-receptors, key metabolic enzymes, etc.).4
To confirm its multi-target potential, Berbevis® has been extensively studied in in vitro, in vivo and human studies where it showed to effectively support metabolic health, favorably modulating insulin response; improving the blood sugar profile, leveling both blood glycemic and insulin; optimizing the blood lipid profile; having a positive effect on body composition and inducing the redistribution of adipose tissue.5,6
Furthermore, other studies highlighted its activity promoting hormonal balance and its positive effect on low-grade chronic inflammation.7
Phytosome™
Find out how Berbevis®
is one step beyond
The uniqueness of Berbevis® derives directly from one of berberine’s main limits: bioavailability. The raw extract is, indeed, characterized by poor oral bioavailability and bioabsorption profile.
The answer is the next-generation Phytosome™ delivery system based on a new custom formulation – specifically designed according to the properties of Berberine – with 3 innovative features. One, pea proteins used as carrier within the Phytosome™ matrix; two, the use of Berberis aristata raw extract, more soluble than pure berberine.
Grape seed extract is the third term of the equation, as a powerful, natural antioxidant to protect the intestinal mucosa against the known gastrointestinal adverse effects of traditional berberine, optimizing its tolerability.8
Thanks to the new custom Phytosome™, Berbevis® is a multi-target food-grade ingredient with and optimized bioabsorption, improving very favorably the original berberine’s bioavailability (on molar basis level and with observed dose linearity).7
Things to Watch
Things to watch
Berbevis®
Keep your metabolism balanced, naturally
Are you curious to discover Berbevis® - Berberine Phytosome® - your natural ally for a healthy metabolism? In just a few minutes, you’ll hear why Berbevis® stands as a promising candidate for the management of a range of multifactorial disorders.
PRODUCTS / 14 Mar 24
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See through science
Peer-reviewed science on Berbevis®
Here you can find more scientific evidence for your review.
ACCESS NOWBibliography
1Imenshahidi M, et al. Phytother Res. 30(11):1745-1764. (2016).
2Kulkarni SK, et al. Eur J Pharmacol. 589(1-3):163-72 (2008).
3Yu F, et al. Eur J Pharm Biopharm.103:136-148. (2016).
4Kong WJ, et al. Pharmacol Ther. 209:107496.(2020).
5Rondanelli M, et al. Nutrients 13 (2021).
6Riva et al. Indena data on file.
7Li MF, et al. Evid Based Complement Alternat Med. 2018:2532935.(2018).
8Ma, Bing-Liang, et al. Scientific reports 6.1:1-11. (2016).
BERBEVIS® AT A GLANCE
Why choose Berbevis®?
01.
Promotes a healthy wellbeing, positively modulating blood sugar levels in a plethora of multifactorial disorders, such as type-II diabetes and PCOS (Polycystic Ovary Syndrome)
02.
Shows an optimized bioabsorption profile thanks to the new custom formulation of Phytosome
03.
Has a pleiotropic effect on several pathways involved in regulating metabolism balance
04.
Hampers the signs and symptoms of metabolic disorders
05.
Supports hormonal balance
06.
Tested in in vitro, in vivo and human studies
07.
It is well tolerated and safe, even for prolonged use
Technical data
Common Name
Berberine phospholipids
Botanical Origin
Berberis aristata
Type
Extract
Plant source
Root
-
Health benefit
Blood glucose homeostasis, Hormonal control , Metabolism balance
Patent & Trademark
Berbevis is a trademark of Indena S.p.A. The use of Indena’s trademarks is subject to Indena’s authorization and to the acceptance of the terms and conditions set out in the Trademark Usage Guidelines downloadable HERE..
Specifications
Berbevis® is standardized to contain 28 – 34% of Berberine by HPLC
Recommended dose and use
2 x 550 mg/day. Berbevis® is a light brown powder, used in a variety of supplement formulations.
Assay
28 – 34% of Berberine by HPLC
Broad category
Healthy Metabolism, Multifactorial Disorders, Hormonal Balance
These statements may not comply with your country’s laws and regulations or with Reg. EC n. 1924/2006 and have not been evaluated by the Food and Drug Administration. The products are not intended to diagnose, treat, cure or prevent any disease. Marketers of finished products containing this ingredient are responsible for ensuring compliance with the applicable legal framework.
Berbevis® documents
