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Go to sectionDiscovered in the 1950s, palmitoylethanolamide (PEA) is the N-acylethanolamine naturally found in a variety of plant and animal food sources, as well as in mammalian tissues; here, it is naturally produced in response to inflammation and stress, to help regulate ache processes.
For this reason, its supplementation has been extensively studied for its remarkable effect on the inflammatory cascade and soothing properties, offering a host of health benefits including relief from chronic ache signals.1
Since more and more people are turning to natural alternatives to manage their chronic ache symptoms, which can have a detrimental impact on daily life and overall well-being, the search for the perfect ally has already started.
The aim? To find a natural remedy that not only helps regulate ache signals, but also teams up with conventional treatments, potentially minimizing their side effects.
Enter Cronilief™: an innovative nutraceutical compound that combines PEA with advanced Indena Phytosome™ technology, unlocking the molecule’s full health benefits to effectively manage chronic ache signals and promote relief.
What makes Cronilief™ so promising as a nutraceutical for chronic ache signals is PEA’s multi-factorial mechanism of action, able to target a plethora of molecules in the body that are involved in the ache signaling pathway.1
PEA multifaceted activity is further exploited thanks to Indena Phytosome™ technology: recent human pharmacokinetics with a repeated administration, randomized, crossover design involving 20 volunteers showed up to 6x optimized bioabsorption.2
These promising benefits are under evaluation in various clinical trials, which are revealing that PEA Indena Phytosome™ may be a useful, well tolerated aid for the management of ache symptoms.
Preliminary results of an interim analysis performed on a randomized, double-blind, placebo-controlled study - have provided evidence supporting the efficacy of Cronilief™ in managing discomfort localized in the lower back. In this trial, Cronilief™ was supplemented at an initial dosage of 600 mg daily for the first 7 days, followed by a maintenance regimen of 300 mg daily for up to 8 weeks.
A significant amelioration in perceived lower back discomfort compared to placebo has been demonstrated, indicating the potential of Cronilief™ as a supportive strategy in the management of this common condition.3
Cronilief™ is a uniquely promising nutraceutical because it provides a solution to one of PEA’s limits: its bioabsorption. Although found to be clinically well tolerated and effective in reducing ache signals, PEA is poorly soluble in water and aqueous environments due to its lipophilic nature, resulting in a low absorption rate.
Here is where the advanced Indena Phytosome™ technology steps in: it enhances the bioabsorption of PEA without altering its structure and tolerability, ensuring food-grade quality.
Altogether, Cronilief™ is an innovative nutraceutical that helps tap into PEA’s full bioactive potential – effectively improving the management of chronic ache signals and symptoms.
Bibliography
1Rankin L. and Christopher J. Fowler. "International Journal of Molecular Sciences 21.21 : 7942 (2020).
2Indena data on file. Manuscript in preparation.
3Indena data on file. Manuscript in preparation.
Persistent discomfort can quietly erode quality of life – but a natural, multidimensional approach can help us respond. Discover Indena’s science-backed strategy to address inflammation, sensory signaling, and emotional well-being.
Cronilief™ is an innovative food-grade product.
PEA provides significant relief for chronic ache signals (proven by in vitro, in vivo, and clinical studies).
PEA has a pleiotropic effect on various signaling pathways.
PEA can modulate inflammatory pathways, including physiological ones.
PEA has been shown to be well tolerated and safe.
Cronilief™ optimizes PEA’s bioabsorption profile thanks to the advanced Indena Phytosome™ technology.
Common Name
Palmitoylethanolamide Indena Phytosome™
Type
Plant source
HALAL Certified
Health benefit
Ache signaling
Patent & Trademark
Cronilief™ is a trademark of Indena S.p.A. The use of Indena’s trademarks is subject to Indena’s authorization.
Specifications
Cronilief™ is standardized to contain 40% mg of PEA
Recommended dose and use
300 mg, twice a day. Cronilief™ is a light brown powder for use in nutritional supplements.
Assay
≥35.0% ≤40.0% of palmitoylethanolamide by HPLC
Broad category
Chronic ache relief
These statements may not comply with your country’s laws and regulations or with Reg. EC n. 1924/2006 and have not been evaluated by the Food and Drug Administration. The products are not intended to diagnose, treat, cure or prevent any disease. Marketers of finished products containing this ingredient are responsible for ensuring compliance with the applicable legal framework.
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