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NUTRACEUTICALS
Ubiqsome®
CoQ10 Phytosome®
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NEW SCIENTIFIC EVIDENCE
The right aim to fight statin-induced asthenia
Ubiqsome® has scored another point for cardiovascular health, unveiling a possible mechanism that leads to statin-induced muscular asthenia, alleviating the side effects of one of the most widely used drugs in the world, and contributing to the maintenance of pre-treatment health conditions.
Indeed, muscular parameters in people taking Ubiqsome®, the original CoQ10 in Phytosome® formulation, are effectively preserved by counteracting statin-induced asthenia, as measured in a strength test.
This stands as further evidence that formulation matters! Because for any bioactive substance, reaching the target is an essential requirement to ensure efficacy; and this is especially true when protection is needed.
Explore the results
Overview
We’ve set the absolute advantage
Coenzyme Q10 (CoQ10), also known as ubiquinone or ubidecarenone, is a key endogenous factor in cell energy production. It has shown protective properties against oxidative stress, mainly in skeletal and heart muscles and, more recently, at the endothelial level.2,3,4
CARDIOVASCULAR OXIDATIVE STRESS PROTECTION
Endothelial function is an important early marker for cardiovascular risk, reflecting the ability of the endothelial layer to fight early pro-atherosclerosis conditions. Since endothelial dysfunction is primarily driven by ROS and NO deficiency, the antioxidant potential of Ubiqsome® could be a valuable ally to maintain the endothelium in good health, beyond any other available on the market.
A recently published study on healthy young people has confirmed this hypothesis, showing an improvement of endothelial function in both acute and chronic settings after the administration of Ubiqsome®.3
MUSCULAR OXIDATIVE STRESS PROTECTION
Reactive oxygen species (ROS) are overproduced during intense training and exercise, contributing to muscular stress and damage. A study on healthy, aging runners showed that the administration of Ubiqsome® optimizes plasmatic and muscular CoQ10 concentration, counteracting oxidative stress right where it’s needed.5
Another recent human study, focusing on cardiovascular subjects, showed Ubiqsome® also has beneficial effects on elderly people with statin-related asthenia. What is the mechanism behind this evidence? Statins act by blocking the molecular pathway that leads to the synthesis of cholesterol, and in parallel also to the formation of CoQ10. Thanks to its original Phytosome® formulation, Ubiqsome® reaches the right cellular concentration and – unlike any other supplement – makes a difference at the muscular level, balancing the induced low levels of CoQ10.1
Ubiqsome® in action
CoQ10 provides essential antioxidant protection, crucial for managing specific health challenges, including some tied to the aging process.4 Skeletal and cardiac muscle cells naturally have the highest CoQ10 content, directly impacting tissue functionality. However, the distribution of dietary CoQ10 is not the same among the different tissues of the human body, with muscle being the least responsive.2
This is where Ubiqsome® emerges as the real game-changer in the field: thanks to its original Phytosome® technology, recent studies have unveiled that this food-grade, highly bioabsorbed Coenzyme Q10 based ingredient excels at delivering its core component to the intended target muscle cells, reaching the goal better and faster.3
Ubiqsome® ensures optimal CoQ10 plasma levels even after just one dose, and shows an evident dose-dependent trend after a mere 2 weeks of supplementation.4
Phytosome®
Find out how Ubiqsome®
is one step beyond
Ubiqsome® is the only CoQ10 formulation to benefit from Indena’s Phytosome® delivery system, a strategy that optimizes the bioabsorption of this important cofactor.
Outstanding clinical results have been accomplished, thanks to the innovative Phytosome® technology platform, also in enhancing one of CoQ10’s limiting factors: oral bioavailability and muscle cells uptake. The coenzyme’s high molecular weight and its very low aqueous solubility usually make it unsuitable for the oral administration route: that’s where the Phytosome® delivery system is particularly useful, improving and optimizing the uptake for more refractory cells and tissues.2,4
In addition, Ubiqsome® is the first CoQ10 formulation to have been tracked down to its real target, the inner space of cells where it is needed.
See through science
Peer-reviewed science on Ubiqsome®
Here you can find more scientific evidence for your review.
ACCESS NOWBibliography
1Cicero at al, Journal of Hypertension 41.1 (2023): e152-e153.
2Marcheggiani et al.; Antioxidants (2023); 12, 964.
3Cicero et al.; Biofactors (2022): 1-6.
4Petrangolini et al.; Current Drug Delivery (2019).
5Drobnic et al.; J Food Sci Nutr Res (2020); 3 (4): 262-275.
UBIQSOME® at a glance
Why choose Ubiqsome®?
01.
Is the optimized delivery form of coenzyme Q10, formulated with Phytosome® technology.
02.
Supported by double-blind pharmacokinetic and human-efficacy studies.
03.
Optimizes CoQ10 plasma levels in a dose-dependent fashion and shows 14-fold higher solubility in simulated intestinal fluids.
04.
Optimizes CoQ10 levels in human muscle and epithelial cells.
05.
Is the first and only CoQ10 formulation on the market to have been tracked from oral administration down to its single, real target: the inner space of cells.
06.
Offers great potential for nutraceutical integration in any situation that requires an effective contribution of coenzyme Q10 for the wellbeing and balance of the body.
07.
Can be a cost-effective solution thanks to optimized bioabsorption – allowing for lower CoQ10 content without relying upon expensive capsulating technologies, as well as industrial scalability and versatile finished oral dosage forms.
08.
Supports the endothelial function’s ability to fight oxidation.
09.
Could be a promising ingredient for cardiovascular health, able to protect from cardiovascular risk factors.
10.
Protects muscle cells from statin-related adverse effects.
Technical Data
Common Name
CoQ10 phospholipids
Type
Ingredient with optimized bioabsorption
Plant source
-
Health benefit
Anti-ageing, Antioxidant protection, Cardiovascular Health, Cellular energy support, Heart health, Muscle protection, Support intensive exercise
Patent & Trademark
Ubiqsome is patented (EP3307244).
Ubiqsome is a trademark of Indena S.p.A. The use of Indena’s trademarks is subject to Indena’s authorization and to the acceptance of the terms and conditions set out in the Trademark Usage Guidelines downloadable HERE.
Specifications
Standardized to contain 18-22% of coenzyme Q10
Recommended dose and use
Up to 500 mg/day. Ubiqsome® may be used in a variety of supplement formulations.
Assay
18-22% of coenzyme Q10 by HPLC
Broad category
Cell bioenergetics support, sports nutrition, healthy aging, heart & cardiovascular health, brain health
These statements may not comply with your country’s laws and regulations or with Reg. EC n. 1924/2006 and have not been evaluated by the Food and Drug Administration. The products are not intended to diagnose, treat, cure or prevent any disease. Marketers of finished products containing this ingredient are responsible for ensuring compliance with the applicable legal framework.
UBIQSOME® documents
