Berbevis® – Berberine Phytosome®
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Berbevis® – Berberine Phytosome®
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Peer-reviewed science on Berbevis®
Contributing to metabolic wellbeing1
Berbevis® has a positive effect on body composition, inducing a redistribution of adipose tissue even if enrolled subjects aren’t under low calories diet (Figure 1,2)1.
Figure 1. Descriptive statistics for the body composition measured at baseline (t0) and after 60 days (t2) of Berbevis® supplementation.W/H: Waist/Hip Ratio; BMI: Body Mass Index. *p<0.05; **p<0.005.
Figure 2. Effectiveness on body composition, inducing a redistribution of adipose tissue with the reduction of the visceral fat tissue and fat mass. * p<0.005.
Lowers blood glucose1
Berbevis® positively modulates insulin resistance (HOMA index) after 30 days of supplementation (Figure3). The homeostatic model assessment (HOMA) is a mathematical formula correlating blood glucose and insulin. It’s a validated method used to quantify insulin resistance and function of pancreatic beta-cells (which produce insulin). The higher is the HOMA score, the higher is the risk of insulin resistance.
Figure 3. Effect of Berbevis® on HOMA index in PCOS individuals (*p≤0.005).
Berbevis® significantly improves blood sugar profile optimizing both glycemia and insulin (Figure 4)1.
Figure 4. Effect of Berbevis® on the glycemic profile in PCOS individuals (*p≤0.005; **p<0.0005).
Berberis Phytosome® optimizes berberine's bioabsorption2
Pharmacokinetic study shows Berbevis® optimized berberine bioavailability (AUC) by ≈ 10 times on molar basis and with observed dose linearity. The pharmacokinetic profile of total and free berberine after administration of Berbevis® and berberine chloride to healthy volunteers is shown in Figure 5.
Figure 5. Statistical analysis was performed by two-way ANOVA, followed by Tukey’s test, *p<0.05 vs A, § p<0.05 vs B. Symbols represent mean values (± standard deviation). Formulations: A: berberine chloride alone 500 mg (equivalent to 452 mg of berberine); B: Berbevis® 550 mg (equivalent to 188 mg of berberine) one film-coated tablet berberine; C: Berbevis®550 mg (equivalent to 188 mg berberine) two film-coated tablets. Twelve healthy volunteers of both sexes with a mean age of 29 ± 7.72 and a mean BMI of 23.09 ± 1.27 were enrolled.
BIBLIOGRAPHY
1Rondanelli M, et al.Nutrients 13 (2021).
2Riva et al. Indena data on file.
