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Relissa™
Relissa™

NUTRACEUTICALS

Relissa™

Melissa Phytosome™

KEEP CALM & RELISSA™
SLEEP WELL AND LIVE BETTER

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BEHIND THE POWER OF REST PURITY, SCIENTIFIC VALIDATION AND SUSTAINABILITY

With its botanical balance, RelissaTM is scientifically proven to contribute to beneficial effects on mental and sleep health in adults with mild sleep problems associated with depression, anxiety, and stress.1

Melissa leaves are a traditional sleep aid, but today we know that – while over 50 compounds have been identified in lemon balm extracts – their biological activity is mostly due to hydroxycinnamic and rosmarinic acids and derivatives.2,3

The bright minds at Indena, therefore, focused on achieving the perfect quantification and formulation of these two chemicals, making RelissaTM a standardized, reliable and melatonin-free supplementation against sleeping difficulties and related symptoms, for a better quality of life.

What’s more, in line with the company’s ongoing efforts to protect the environment, this pure ingredient is also part of the journey of sustainability that Indena is driving forward with great commitment.

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OVERVIEW

We’ve set the absolute advantage

The leaves of Melissa officinalis are the starting point of the process, as they provide bioactive compounds responsible for several biological activities, including the promotion of sleep, relaxation, and calm.3,4,5,6,7

But Relissa™ is not a common melissa extract: it stands out for its high content of hydroxycinnamic and rosmarinic acid, quantified and standardized for better and effective results, and delivered thanks to the innovative Phytosome™ technology.2

We’ve set the absolute advantage

Relissa™ into action

Melissa officinalis has been known for centuries and used for various applications thanks to its calming and “antistress” action, promoting sleep and relaxation. Other investigated effects of the botanical include antioxidant and spasmolytic activity, neuroprotection, and anxiolytic action.3,4,5,6,7

The beneficial effects on sleep and mental wellness have recently been shown on adults after 3 weeks of Relissa™ supplementation in a double-blind randomized clinical study.1

In addition, a specific potential interaction was closely analyzed to dispel any concern within the context of recent increased interest in how the microbiome may influence our wellbeing, especially in the realm of mood and sleep.

Lactobacillus rhamnosus – a type of bacteria that is able to colonize the human gastrointestinal tract – has been proven able to improve night rest and rapid eye movement (REM) sleep8, thanks to a positive influence over short-chain fatty acids (SCFAs) controlling the expression of genes responsible for sleep-wake rhythms.9 Relissa™ has shown no negative interactions with Lactobacillus rhamnosus, thus safeguarding its beneficial effect.10

Relissa™ into action

Find out how Relissa™
is one step beyond

Relissa™ is formulated with Indena’s Phytosome™ strategy to create phospholipidic molecules, allowing a better dispersion in gastrointestinal fluids and enhancing the ingredient’s bioaccessibility profile. The Phytosome™ technology platform grants the active ingredients contained in Mellissa officinalis offer better biological performances, while still fully respecting their natural profile.2

Leveraging the same technology, Relissa™ can also be provided in the form of gummies, an increasingly popular solution on the supplement market.

Find out more on Phytosome™

Relissa™’s sustainable journey

Relissa™ is a new ingredient by Indena, yet reflects all of the company’s milestones and solid values: 100 years of scientific background, innovative formulation solutions and attention to botanical sources.

Indeed, the best Melissa officinalis extracts chosen for Relissa™ not only comply with Indena’s high standards but are also part of a sustainable journey that keeps a careful eye on carbon footprint. The goal is to always select the most virtuous and organic farms and suppliers based in Europe, which can guarantee high quality and environmental awareness at the same time.

These elements translate in a production cycle that has evolved along a virtuous and eco-sustainable path, using driers powered by renewable energy, leveraging waste-heat from systems that run on biogases generated from the fermentation of agro-industrial by-products, and feeding back leftover biomasses into the growing phase, as a soil conditioner.

See through science

Bibliography
1. Bano A, et al. (2023) Front. Pharmacol. 14:1250560. doi: 10.3389/fphar.2023.1250560
2. Indena internal data.
3. Shakeri F. et al., Journal of ethnopharmacology 188 (2016): 204-228.
4. Świąder J., Appl. Bot. Food Qual 92 (2019): 327-335.
5. European Commission Monograph – Melissa officinalis.
6. ESCOP – Melissa officinalis.
7. WHO Monograph – Folium Melissae.
8. Thompson R.S. et al., Front Behav Neurosci 2017.
9. Dalile B. et al., Nat Rev Gastroenterol Hepatol 2019.
10. Indena internal data.

Relissa™ AT A GLANCE

Why choose Relissa™?

01.

Supported by a double-blind randomized human study, which confirmed its positive effects on sleeping and mental health.

02.

Contains a high and standardized concentration of hydroxycinnamic and rosmarinic acids.

03.

Improves and optimizes the distribution in gastrointestinal fluids and absorption profile thanks to Phytosome™ delivery system.

04.

Shows recognized activity promoting healthy sleep and relaxation.

05.

Shows no interaction with Lactobacillus rhamnosus – a bacteria able to colonize the gastrointestinal tract – it has been proven able to improve night rest and rapid eye movement (REM) sleep.

06.

Made with plants of European origin.

07.

Part of Indena’s commitment to maximize sustainability and minimize environmental footprint.

08.

Subject of ESCOP, WHO and EMA monographs.

09.

Can also be formulated in gummies, an increasingly popular solution on the market.

Technical data

Common Name

Melissa phospholipids

Botanical Origin

Melissa officinalis L.

Type

Extract

Plant source

Leaves

Health benefit

Calming action, Healthy sleep, Relaxation

Patent & Trademark

Relissa™ is a trademark of Indena S.p.A. The use of Indena’s trademarks is subject to Indena’s authorization and to the acceptance of the terms and conditions set out in the Trademark Usage Guidelines downloadable HERE.

Specifications

Optimized bioabsorption profile.

Recommended dose and use

200 - 400 mg/day.
Relissa™ may be used in a variety of supplement formulations.

Assay

17-23% of lemon balm by HPLC

Broad category

Healthy Sleep, Calm & Relaxation

Relissa™ documents

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