Joining forces to help ease aches
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健康食品
Mitidol®
Standardized combination of ginger & acmella oleracea
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Overview
We’ve set the absolute advantage
Ginger (Zingiber officinale Roscoe) is an excellent source of several bioactive phenolics, including non-volatile pungent compounds, especially gingerols and shogaols whose major properties embrace immunomodulatory, anti-inflammatory, anti-hyperglycemic, antiemetic and antilipidemic actions.1
Acmella (Acmella oleracea L.) has been used for centuries to manage oral and topical pain because of its analgesic properties.
Studies have shown that Spilanthol is the principal compound that promotes local anesthetic action and has many other biological activities such as analgesic, antinociceptive, antioxidant, anti-inflammatory and anti-wrinkles.2
Born from the smart combination of these 2 standardized extracts and exploiting the synergy of this amazing couple, Mitidol® is an innovative natural solution which have been developed to provide an effective ache management support.
Indena proprietary Acmella plantations in Italy guarantee a fully controlled supply chain.
Mitidol® into action
Two recent in vitro experiments has clarified Ginger and Acmella mechanism of action, proving that their combination in the Mitidol® formulation has a double effect on ache relief support: a direct one thanks to the interaction with the cannabinoid receptor CB2 and an indirect one through the inhibition of FAAH enzyme, involved in the physiological ache relief processes.3
Moreover, the powerful combination of the 2 extracts support knee functionality and comfort, according to a one-month human trial conducted on 50 subjects with knee challenge.4
Find out how Mitidol®
is one step beyond
Starting from the commitment toward the choice of the best raw materials (Sardinia proprietary cultivation to optimize the quality of the Acmella biomass), toward the use of technological formulative solutions (the blend of 2 oily liquid extract transformed in a unique fine-powder ingredient), Mitidol® is the result of Indena’s scientific expertise in the field of ache management support.
Things to watch
Things to watch
脳の健康
心を養い、人生を満たす
脳は、あなたをあなたたらしめています。 人生のペースが私たちの精神的な幸福を困難にするとき、自然は具体的な解決策を提供してくれます。 脳の健康を育み、人生を最大限に楽しむために厳選された、インデナを代表する4つの植物エキスをお試しください。
HEALTH STORIES / 12 5月 25
6.23
See through science
Peer-reviewed science on Mitidol®
Here you can find more scientific evidence for your review.
ACCESS NOWBibliography
1 Rondanelli M., et al., Phytotherapy Research 34(11):2843-56 (2020).
2 Rondanelli M., et al., Fitoterapia 140: 104419 (2020).
3 Petrangolini G. et al., J Nutr Food Sci, 10:766 (2019).
4 Rondanelli M., et al., Journal of Pain Research, 761-70 (2020).
Mitidol® at a glance
Why choose Mitidol®?
01.
Mitidol® is a smart combination of Acmella and Zingiber extracts working together in a powerful way: as reported by literature data, both plants can be useful as ache signaling modulators.
02.
Mitidol® is supported by human efficacy studies and in vitro mechanistic studies.
03.
Mitidol® is proven twice as active on the endocannabinoid system (CB2 and FAAH in vitro models).
04.
Mitidol® contributes to relief from knee challenges.
05.
Mitidol® optimizes knee function (confirmed with WOMAC and Lhysolm scale).
06.
Mitidol® is a fine powder perfect for solid dosage forms.
07.
Mitidol® sports a fully controlled supply chain, with proprietary Acmella plantations in Italy.
Technical Data
一般名
Acmella and Zingiber standardized extracts
基原植物
Acmella oleracea (I) R.K. Jensen / Aerial part Zingiber officinale Roscoe
種類
Extract
植物部位
Rhizome (Zingiber), Aerial part (Acmella)
健康上の効能
Ache signaling, 炎症反応を正常に, 痛み止め
Patent & Trademark
Mitidol is patented (EP3554523).
Mitidol is a trademark of Indena S.p.A The use of Indena’s trademarks is subject Indena’s authorization.
Specifications
350 mg twice a day. Mitidol® is a yellowish fine powder with good technological properties (e.g. density, flowability), easy to formulate and mainly suitable for capsules and tablets.
Recommended dose and use
A combination of ginger and acmella with innovative formulation which blends the 2 oily liquid extracts in a unique fine-powder ingredient.
アッセイ
9.6-11.8% Zingiber officinale CO2 extract (2.4-3.9% total gingerols and shogaols by HPLC); 1.9-2.4% Acmella oleracea st. extract (0.30-0.60% spilanthol by HPLC)
広義のカテゴリー
Chronic ache relief
These statements may not comply with your country’s laws and regulations or with Reg. EC n. 1924/2006 and have not been evaluated by the Food and Drug Administration. The products are not intended to diagnose, treat, cure or prevent any disease. Marketers of finished products containing this ingredient are responsible for ensuring compliance with the applicable legal framework.
Mitidol® documents
News about Mitidol®
ニュース / 15 12月 20
Ginger and Acmella, together in Mitidol®: a smart couple for effective ache relief support
Indena has been focusing for years in developing a supportive ingredient to face one of the most relevant global health issues: ache management. The result is Mitidol®, an amazing combination of 2 botanicals working together very effectively: ginger and acmella.
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