バズガード®
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セクションに移動Peer-reviewed science on Vazguard®
In a double-blind placebo-controlled study, Vazguard® could significantly optimize by -12% the abdominal fat in healthy volunteers:
- significant results could be observed within 1 month
- the optimization of abdominal fat translated into a global improvement of the glycolipidemic profile
- the LDL/HDL cholesterol was significantly optimized
- a beneficial effect was also observed on lipoproteins Apo-A and Apo-B
- the improvement of the lipid profile could also be observed in a wide population in terms of age and gender.
- a moderate optimization of glycemia was observed, along with a more significant beneficial effect on insulin resistence parameters (HOMA), thus suggesting a support of Vazguard® on the control of appetite
- the supplementation supported also the normalization of liver function as reflected by transaminases
Vazguard® showed potential efficacy in decreasing Firmicutes and Bacteroidetes, the intestinal microbiota associated with obesity, diabetes and cardiovascular risk.
図1:総コレステロール(totChol)、LDLコレステロール(cLDL)、HDLコレステロール(cHDL)、トリグリセリド(TG)および血糖値(BGluc)に対するベルガモットポリフェノール分画(BPF)の介入前後の効果。
Vazguard® demonstrated to have an activity on gut microflora involved in genesis of abdominal fat, obesity and diabetes.
BPFのフィトソーム®製剤は、標準製剤と比較して最適な吸収を示しています。被験者60人を対象に実施したヒト試験(20人にを投与)では、フィトソーム®製剤と比較して、バズガード®の生体吸収が2.5倍増加することが示されています。
フィトソーム®送達システムを使用した場合、cHDLの有益な活用に伴い、空腹時血漿グルコース、血清中cLDLおよびトリグリセリドの有意な平準化も認められています。
図2:標準的なベルガモットポリフェノール分画(BPF)およびベルガモットポリフェノール分画(BPF)フィトソーム®製剤摂取後の血漿中のナリンギンプロファイル。
参考文献
1- Formisano C. et al,J. Agric. Food Chem. 2019, 67, 3159−3167;
2- Di Donna L et al J Nat Prod 72:1352–1354 5 (2009)
3- Mollace V. et al.,Endocrine Metabolic& Immune Disorders – Drug Targets 2019, 19, 136-143;
4- Rondanelli M. et al., Phytotherapy Res. 2020, in press;
5- Ramaschi G.,et al, J. Agric. Food Chem. 2019, 67, 3159−3167
6- Riva A. et al., J Appl.Microb Res. 2020, 3 (2), 45-51.
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