KEEP YOUR METABOLISM BALANCED, NATURALLY
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Berbevis®
Berberine - Indena Phytosome™
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Berbevis® is 2025 Ingredient of the Year: Botanicals!
Indena’s Berberine Indena Phytosome™ has emerged as the top ingredient for the Botanicals category at the 8th NutraIngredients-USA Awards. Hosted annually by NutraIngredients.com, this prestigious event honors innovation and excellence across the global nutrition and dietary supplements industry.
This recognition affirms our dedication to harnessing the best of nature through rigorous science, delivering clinically backed solutions like Berbevis®, designed to support today’s most pressing health needs with proven efficacy and superior absorption.
Overview
We’ve set the absolute advantage
For centuries, plants from the Berberis genus have been widely used in traditional Asian medicine for their health benefits; among them, a particular species – Berberis aristata – is also mentioned in the Ayurvedic Pharmacopoeia of India.
From a scientific point of view, berberine is recognized as a natural bioactive alkaloid obtained from plants belonging to the Berberis genus, proven to favorably modulate blood profiles such as plasma lipids and glucose levels, contributing to metabolic wellbeing, and supporting hormone balance to smooth skin imperfections.
Finding a way to keep our metabolism balanced is one of our time’s main global health targets, as a springboard to ease parameters specific of multifactorial noncommunicable conditions (such as metabolic syndrome, Polycystic Ovary Syndrome - PCOS - or prediabetes).
This urgent need started the journey that led to Berbevis®, your natural ally for a healthy metabolism: an innovative berberine extract obtained from Berberis aristata with an optimized bioabsorption profile, thanks to the Indena Phytosome™ delivery system: it is in fact capable to support healthy weight management (including blood and glucose healthy metabolism and anthropometric parameter) and a healthy skin in different stages of life.
Berbevis® into action
In recent years, berberine has received widespread attention due to its good potential for optimal metabolic wellbeing during our lifespan.
Its efficacy is linked to the berberine’s so-called “Cloud Effect”: its pleiotropic action that simultaneously affects both root causes (e.g. low-grade chronic inflammation, oxidative stress, gut microbiota modulation) and visible effects (e.g. insulin response) through the modulation of several cellular targets (e.g. AMPK, mitochondria, insulin-receptors, key metabolic enzymes).1
To confirm its multi-target potential, Berbevis® has been extensively studied in in vitro, in vivo and human studies where it showed to effectively support metabolic health: favorably modulating insulin response; optimizing blood profile (leveling both glucose and lipid metabolisms); having a positive effect on body composition.2,3
One of the most recent studies on Berbevis®, for example, has shown that it is possible to reshape the path of near-to-hyperlipidemic subjects with a single administration of Berbevis® a day, balancing their lipid profile and favorably affecting body composition.3
A recent clinical study confirmed that Berbevis® can be a valuable support for heart and blood vessel health. In people with altered cholesterol levels, taking 550 mg per day for six months helped keep important risk factors for atherosclerosis—like blood vessel function and homocysteine levels—in balance.4
These findings show that Berbevis™ is not only effective but also safe to use over the long term, making it a strong ally in maintaining cardio-metabolic well-being.
Furthermore,other studies highlighted the ingredient's activity promoting hormonal balance and its positive effect on low-grade chronic inflammation.
In particular, in women dealing with PCOS, Berbevis® is significantly able to ameliorate skin discomforts, contributing to an improved quality of life. 5
As an added confirmation on the ingredient safety, Berbevis® demonstrated no evidences of negative interactions during undergoing selected chronic therapies.6
Find out how Berbevis®
is one step beyond
The unique strength of Berbevis® is directly connected to one of berberine’s main limits: bioavailability. The raw extract is, indeed, characterized by a poor oral bioavailability and bioabsorption profile.
The solution to this is the next-generation Indena Phytosome™ delivery system based on a new custom formulation – specifically designed according to the properties of berberine – with 3 innovative features. The first one is the use of pea proteins as carrier within the Indena Phytosome™ matrix; the second, the use of Berberis aristata raw extract, which is more soluble than pure berberinee.
Grape seed extract is the third term in the equation, serving as a powerful, natural antioxidant to protect the intestinal mucosa against the known gastrointestinal adverse effects of traditional berberine, optimizing its tolerability.
The new custom Indena Phytosome™ makes Berbevis® a multi-target food-grade ingredient with optimized bioabsorption, marking a great improvement on the original berberine’s bioavailability (on molar basis level and with observed dose linearity).7
Things to Watch
Things to watch
Beauty From Within
Find your inner health, and let it show.
What if beauty wasn’t just something you see, but something you feel? Find out how Indena is redefining the importance of looks through a holistic, science-backed approach that starts from within – thanks to targeted botanical ingredients that help nourish skin, hair, and nails by supporting the body’s internal balance.
HEALTH STORIES / 23 7月 25
3.15
See through science
Peer-reviewed science on Berbevis®
Here you can find more scientific evidence for your review.
ACCESS NOWBibliography
1Kong WJ, et al. Pharmacol Ther. 209:107496. (2020).
2Rondanelli M. et al.; Eur Rev Med Pharmacol Sci. Jul;27(14):6718-6727 (2023).
3Cesarone MR, et al. Minerva Gastroenterol (Torino).70(1):10-15. (2024).
4Cesarone, Maria R., et al. Minerva medica (2025).
5Rondanelli M. et al.; Nutrients. Oct 19;13(10):3665 (2021).
6Cesarone MR. et al. Austin J Cardiovasc Dis Atherosclerosis; 11(2): 1065 (2024).
7Petrangolini G. et al.; Evid Based Complement Alternat Med. Nov (2021)
BERBEVIS® AT A GLANCE
Why choose Berbevis®?
01.
Berbevis® promotes a healthy wellbeing, positively modulating blood sugar levels in a plethora of multifactorial metabolic.
02.
Berbevis® is the perfect ally to maintain healthy blood lipid and glucose profiles.
03.
Berbevis® has also a positive effect on women with PCOS, resulting in an ameliorated healthy inflammatory response and better skin appearance.
04.
Berbevis® positively modulate body composition (anthropometric parameters and fat/muscle ratio).
05.
Berbevis® shows a better bioabsorption profile and an optimized gastrointestinal tolerability thanks to a custom Indena Phytosome™ formulation.
06.
Berbevis® has a pleiotropic effect on several pathways involved in regulating metabolism balance.
07.
Berbevis® well tolerated and safe, even for prolonged use.
08.
Berbevis® is supported by a no-interactions human study with common pharmacological therapies.
HEALTH NEED
Beauty from within
The path to visible beauty lies beneath the surface: follow nature’s guide to nurture skin, hair, and overall vitality from the inside out. Our powerful botanical ingredients help reduce oxidative stress, slow the signs of aging, and support a glowing, resilient appearance – naturally.
HEALTH NEED
Weight loss companions
GLP-1 agonists are reshaping weight management – but not without challenges. Our botanical ingredients are designed to accompany the weight loss journey before, during, and after treatment, helping to counter side effects and support metabolic balance.
Technical data
一般名
Berberis aristata standardized extract phospholipids
基原植物
Berberis aristata
種類
Extract
植物部位
Root
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健康上の効能
代謝バランス, 健康な血中濃度, 肌の健康
Patent & Trademark
Berbevis is a trademark of Indena S.p.A. The use of Indena’s trademarks is subject to Indena’s authorization.
Specifications
Berbevis® is standardized to contain 28 – 34% of Berberine by HPLC
Recommended dose and use
550 mg once or twice a day
アッセイ
28 – 34% of Berberine by HPLC
広義のカテゴリー
Beauty from within, Weight loss companions
These statements may not comply with your country’s laws and regulations or with Reg. EC n. 1924/2006 and have not been evaluated by the Food and Drug Administration. The products are not intended to diagnose, treat, cure or prevent any disease. Marketers of finished products containing this ingredient are responsible for ensuring compliance with the applicable legal framework.
Berbevis® documents
